OZEMPIC

Description

Ozempic (semaglutide) is a GLP-1 receptor agonist used primarily for the management of type 2 diabetes and, more recently, for weight loss. Here are the detailed specifications for Ozempic:

 Active Ingredient
– Semaglutide: A GLP-1 (glucagon-like peptide-1) receptor agonist.

Indications
– Type 2 Diabetes Mellitus: To improve glycemic control in adults.
– Weight Management: Used off-label for weight loss due to its appetite-suppressing properties.

Formulation
– Subcutaneous Injection: Available in pre-filled pens.

Dosage Forms
– 0.25 mg/0.5 mL: Initiation dose, not for glycemic control.
– 0.5 mg/0.5 mL: Starting maintenance dose.
– 1 mg/0.5 mL: Higher maintenance dose.
– 2 mg/0.75 mL: For those needing further glycemic control.

 Administration
– Route: Subcutaneous injection.
– Frequency: Once weekly, on the same day each week, at any time of day, with or without meals.
– Sites: Abdomen, thigh, or upper arm. Rotation of injection sites is recommended.

 Mechanism of Action
– GLP-1 Receptor Agonist: Mimics the incretin hormone GLP-1, enhancing insulin secretion, suppressing glucagon secretion, slowing gastric emptying, and promoting satiety.

 Pharmacokinetics
– Absorption: Peak plasma concentrations reached approximately 1-3 days post-administration.
– Half-Life: Approximately 7 days, supporting once-weekly dosing.
– Metabolism: Primarily metabolized by proteolytic cleavage of the peptide backbone.
– Excretion: Eliminated through urine and feces.

Storage
– Refrigeration: Store pens in a refrigerator at 2°C to 8°C (36°F to 46°F).
– Room Temperature: Pens in use can be kept at room temperature (up to 30°C or 86°F) for up to 56 days.